Maria Leiza Vitale

Thèmes

• Hormones
• Actine
• Cytosquelette
• Connexines
• Diabète
• Myosines
• hypophyse

Intérêts de recherche

• Rôle des jonctions lacunaires dans la physiologie hypophysaire
• Rôle du cytosquelette d’actine dans la régulation de la sécrétion hormonale et dans l’apoptose
• Mécanismes de régulation de la sécrétion hormonale

• Nous avons démontré le rôle essentiel des jonctions lacunaires entre les cellules folliculostellaires dans la physiologie hypophysaire
• Nous avons démontré le rôle du cytosquelette d’actine dans le contrôle de la sécrétion de prolactine
• Nous avons démontré le rôle différentiel des isoformes de la myosine non-musculaire dans divers phénomènes cellulaires.

• Pelletier R.-M, Layeghkhavidaki H †, Seidah NG, Prat A, Vitale ML. "PCSK9 contributes to the cholesterol, glucose and insulin2 homeostasis in seminiferous tubules and maintenance of immunotolerance in testis" Frontiers in Cell and Developmental Biology-Molecular and Cellular Reproduction 10:April 2022; doi: 10.3389/fcell.2022.889972
• Pelletier R-M, Layeghkhavidaki H†, Vitale ML. Glucose, Insulin, Insulin receptor subunits α and β in normal and spontaneously diabetic and obese ob/ob and db/db infertile mouse testis and hypophysis. Reproductive Biology and Endocrinology 2020. doi.org/10.1186/s12958-020-00583-2
• Pelletier R-M, Layeghkhavidaki H†, Kumar NM, Vitale ML. Reciprocal expression of Cx30.2, Cx43, Cx46 and Cx50 in normal and spontaneously diabetic and obese ob/ob and db/db mice and insulin receptor α and β in Cx30-2-/- mice testis and hypophysis. American Journal of Physiology, Regulatory, Integrative and Comparative Physiology 2020; 318: R1078-R1090.
• Pelletier R-M, Akpovi CD†, Chen L‡, Vitale ML. Cholesterol metabolism and Cx43, Cx46, Cx50 expression in normal and spontaneously diabetic and obese ob/ob and db/db mouse testes. American Journal of Physiology. Endocrinology and Metabolism 2018; 314: E21-E38.
• Vitale ML García CJ*, Akpovit CD†, Pelletier R-M. Distinctive actions of connexin 46 and connexin 50 in anterior pituitary folliculostellate cells. PLoS ONE 2017 12 (7):e0182495.
• Vitale ML, Barry A*. Biphasic effect of bFGF on anterior pituitary folliculo-stellate TtT/GF cell coupling, and connexion 43 expression and phosphorylation. Journal of Neuroendocrinology. 2015; 27:787-801.
• Pelletier R-M, Akpovi CD+, Chen L, Kumar N, Vitale ML. Complementary regulation of Cx46 and Cx50 expression and phosphorylation in development and following gene deletion in mouse and in normal and orchitic mink testes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2015; 309: R255-R276.
• Akpovi CD, Anago EAA, Segbo JAG, Manindji C, Medehouenou TCM, Loko F, Vitale ML, Pelletier R.-M. Blood biochemical parameter levels vary with spermatogenesis in seasonal reproductive model the mink (Mustela vison).
• Solinet S, Akpovi CD, Garcia GJ*, Barry A*, Vitale ML Myosin IIB deficiency in embryonic fibroblasts affects regulators and core members of the par polarity complex. Histochemistry and Cell Biology 2011;136:245-266
• Pelletier R-M, Akpovi CD, Chen L, Day R, Vitale ML Cx43 expression, phosphorylation and distribution in the normal and autoimmune orchitic testis with a look at gap junctions joining germ cell-t-germ cells. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2011;300:R121-R-139.