Gilles Hickson

Sciences de la santéSciences médicales
Professeur titulaire
Faculté de médecine - Département de pathologie et biologie cellulaire
514 345-2189
514 345-4731 (Télécopieur)

Expertise de recherche


  • Cytokinèse
  • Anilline
  • Septines
  • Cytosquelette
  • Actine
  • Signalisation de la GTPase Rho
  • Division cellulaire
  • Myosine
  • Midbody (corps centrale)
  • Drosophile

Intérêts de recherche

  • Les mécanismes moléculaires de la cytokinèse
  • La transition de l’anneau contractile à l’anneau du midbody («corps centrale »)
  • Le contrôle du cytosquelette d’actine de myosine et de septines par la protéine d’échaffaudage, l’Anilline
  • Les variations développementales de la cytokinèse en utilisant la drosophile comme modèle
  • L’implication potentielle de la machinerie de la cytokinèse dans la migration cellulaire et la cancérogenèse

Affiliations de recherche UdeM

Prix et distinctions

  • Bourse Postdoctorale de la Fondation Komen for the Cure (2004-2007)
  • Special Fellow de la Société Leukemia & Lymphoma Society (2007-2010)
  • Genetics Society of America, DeLill Nasser Travel Award (2008)
  • FRQS Chercheur Boursier, Junior 1 (2009-2013)
  • FRQS Chercheur Boursier, Junior 2 (2014-2017)
  • FRQS Chercheur Boursier, Sénior (2017-2021)
  • Finaliste, Prix de Nouveau Investigateur Maud Menten 2014, Institut de Génétique, IRSC/CIHR
  • Transition Award de la Fondation Cole (2013)
  • Subvention de fonctionnement des IRSC/CIHR (2009-2019, 2022-2027)
  • Subvention de fonctionnement du CRSNG/NSERC (2014-2026)
  • Subvention d’infrastructure de la Fondation Canadienne pour l’Innovation


  • Hickson, G. R. (2022). A back-up source of microtubules for the midbody during cytokinesis. J. Cell Biol. 221: e202201028. doi: 10.1083/jcb.202201028.
  • Carim, S.*, Kechad, A.* & Hickson, GRX. (2020) Hypothesis and Theory: The Rho-dependent actomyosin-anilloseptin contractile ring as a membrane microdomain gathering, compressing and sorting machine. Front Cell Dev Biol 8:575226. doi: 10.3389/fcell.2020.575226.
  • El-Amine, N.*, Carim, S.*, Wernike, D*. & Hickson, GRX. (2019) Rho-dependent control of the Citron kinase, Sticky, drives midbody ring maturation. Mol. Biol. Cell 30(17): 2185-2204. doi: 10.1091/mbc.E19-04-0194
  • Carim, S.C., El Kadhi, K.B., Yan., G., Sweeney, S.T., Hickson, G.R., Carréno, S. and Lowe, M. (2019) IPIP27 coordinates PtdIns (4,5) P2 homeostasis for successful cytokinesis. Curr. Biol. 29(5) 775-789.
  • Jananji, S., Risi, C., Lindamulage, I.K., Picard, L-P, Van Sciver, R., Laflamme, G., Albaghjati, A.,  Hickson, G.R*, Kwok., B. H.*, and Galkin, V.E.* Multimodal and polymorphic interactions between anillin and actin: their implications for cytokinesis. J. Mol. Biol. 2017. pii: S0022-2836(17)30061-X. doi: 10.1016/j.jmb.2017.01.020 *auteurs co-correspondants.
  • Kechad, A & Hickson, G. R. (2017). Imaging cytokinesis of Drosophila S2 cells. Methods Cell Biol. 2017;137:47-72. doi: 10.1016/bs.mcb.2016.03.034
  • Rodrigues, N.T., Lekomtsev, S., Jananji, S., Kriston-Vizi, J., Hickson, G.R., Baum, B. (2015) Kinetochore-localized PP1/Sds22 induces anaphase polar relaxation to couple chromosome segregation to cytokinesis. Nature, 524(7566):489-92
  • Kachaner, D.*, Pinson, X.*, Ben El Khadi, K., Normandin, K., Talje, L., Carréno, S., Kwok, B., Hickson, G.R. and Archambault, V. (2014) Inter-domain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.*Contributions égales. J. Cell Biol. 207(2):201-11
  • El Amine, N, Kechad, A$, Jananji, S. and Hickson, G.R. (2013).  Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring. J. Cell Biol. 203(3):487-504
  • Wang, P., Galan, J., Normandin, K., Bonneil, E., Hickson, G.R., Roux, P.P., Thibault, P., & Archambault, V. (2013) Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression. J. Cell Biol. 202: 277-93
  • Kechad, A$, Jananji, S., Ruella, Y. and Hickson, G.R. (2012).  Anillin acts as a bifunctional linker coordinating midbody ring biogenesis during cytokinesis. Curr. Biol. 22: 197-203
  • Smurnyy, Y., Toms, A. V., Hickson, G. R., Eck, M. J. and Eggert, U. S. (2010). Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. ACS Chem Biol, 5(11):1015-20. doi: 10.1021/cb1001685
  • Hickson, G. R.* and O’Farrell, P. H. (2008). Rho-dependent control of Anillin behavior during cytokinesis. J. Cell Biol. 180: 285-294 (*auteur correspondant)
  • Hickson, G. R., Echard, A. and O’Farrell, P. H. (2006). Rho-kinase controls cell shape changes during cytokinesis.  Curr. Biol. 16: 359-370
  • Fielding, A. B., Schonteich, E., Matheson, J., Wilson, G., Yu, X., Hickson, G. R., Srivastava, S., Baldwin, S. A., Prekeris, R. and Gould, G. W. (2005).  Rab11-FIP3 and Rab11-FIP4 interact with Arf6 and the Exocyst to control membrane traffic during cytokinesis. Embo J. 24: 3389-99
  • Echard, A*, Hickson, G. R.*, Foley, E. and O’Farrell, P. H. (2004).  Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14: 1685-1693 (*contributions égales)
  • Riggs, B., Rothwell, W., Mische, S., Hickson, G. R., Matheson, J., Gould, G. W., Hays, T. S., and Sullivan, W. (2003)  Actin cytoskeleton remodeling during metaphase and cellular furrow formation requires recycling endosome components Nuclear-fallout and Rab11.  J. Cell Biol., 163: 143-54 (voir news and views in brief, Nature 425, 914)
  • Hickson, G. R., Matheson, J., Riggs, B., Maier, V. H., Fielding, A. B., Prekeris, R., Sullivan, W., Barr, F. A., and Gould, G. W. (2003).  Arfophilins are dual Arf/Rab11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout.  Mol. Biol. Cell, 14: 2908-2920
  • Parry, D. H., Hickson, G. R., and O’Farrell, P. H. (2003).  Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase.  Curr. Biol. 13: 647-653
  • Hickson, G. R., Chamberlain, L. H., Maier, V. H., and Gould, G. W. (2000).  Quantification of SNARE protein levels in 3T3-L1 adipocytes: implications for insulin-stimulated glucose transport.  Biochem. Biophys. Res. Commun. 270:841-845